Substitution at R3 that has a halogen or alkoxy group (74f–74i) triggered a slight increase in mobile potency While using the halide analogs (74g–h) demonstrating optimum the potency from the group. Even more optimization brought about the invention of 74i–j, with 74k as the most Energetic compound inside the collection https://elliottictiz.blogdigy.com/about-indazole-synthesis-review-46991086