Pentobarbital will reduce the extent or influence of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If struggling to prevent coadministration of stiripentol with powerful CYP3A4 inducers, increase stiripentol dose. pentobarbital will reduce the extent or influence of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism... https://englandb442sfr5.thekatyblog.com/profile