Phenobarbital will reduce the extent or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. fluconazole will enhance the degree or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. primidone will minimize the extent or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 me... https://llahp888dpa1.blogdomago.com/profile