Although the opiate receptor depends on G protein coupling for sign transduction, this receptor was discovered to make the most of arrestin activation for internalization of the receptor. Or else, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable enhancement in binding efficacy. https://landencwjlb.blogzet.com/how-much-you-need-to-expect-you-ll-pay-for-a-good-conolidin-to-replace-traditional-painkillers-53112402